Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI models to be used clinically, they need to be made safe, reproducible and robust, and the underlying software framework must be aware of the particularities (e.g. geometry, physiology, physics) of medical data being processed. This work introduces MONAI, a freely available, community-supported, and consortium-led PyTorch-based framework for deep learning in healthcare. MONAI extends PyTorch to support medical data, with a particular focus on imaging, and provide purpose-specific AI model architectures, transformations and utilities that streamline the development and deployment of medical AI models. MONAI follows best practices for software-development, providing an easy-to-use, robust, well-documented, and well-tested software framework. MONAI preserves the simple, additive, and compositional approach of its underlying PyTorch libraries. MONAI is being used by and receiving contributions from research, clinical and industrial teams from around the world, who are pursuing applications spanning nearly every aspect of healthcare.

步态冻结（FOG）是帕金森氏病的最常见症状之一，这是中枢神经系统的神经退行性疾病，影响了世界各地数百万的人。为了满足提高雾的治疗质量的紧迫需求，设计雾计算机辅助检测和量化工具的需求越来越重要。作为一种用于收集运动模式的非侵入性技术，从压力敏感步态垫中获得的脚步压力序列为评估诊所和家庭环境中的雾气提供了绝佳的机会。在这项研究中，提出了雾检测为一项顺序建模任务，并提出了一种新颖的深度学习结构，即对对抗性时空网络（ASTN），提出了跨多个级别的雾模式。引入了一种新型的对抗训练方案，并具有多级主题鉴别器，以获得独立的雾代表示，这有助于降低由于高主体间方差而导致的过度拟合风险。结果，对于看不见的受试者，可以实现强大的雾检测。拟议的计划还阐明了从其他场景中改善主题级临床研究，因为它可以与许多现有的深层建筑集成在一起。据我们所知，这是基于脚步压力的雾检测的最早研究之一，利用ASTN的方法是追求独立于主题的表示形式的第一个深神经网络架构。从21名受试者收集的393次试验的实验结果表明，AUC 0.85的雾检测提出的ASTN表现令人鼓舞。

In this paper, we propose a novel technique, namely INVALIDATOR, to automatically assess the correctness of APR-generated patches via semantic and syntactic reasoning. INVALIDATOR reasons about program semantic via program invariants while it also captures program syntax via language semantic learned from large code corpus using the pre-trained language model. Given a buggy program and the developer-patched program, INVALIDATOR infers likely invariants on both programs. Then, INVALIDATOR determines that a APR-generated patch overfits if: (1) it violates correct specifications or (2) maintains errors behaviors of the original buggy program. In case our approach fails to determine an overfitting patch based on invariants, INVALIDATOR utilizes a trained model from labeled patches to assess patch correctness based on program syntax. The benefit of INVALIDATOR is three-fold. First, INVALIDATOR is able to leverage both semantic and syntactic reasoning to enhance its discriminant capability. Second, INVALIDATOR does not require new test cases to be generated but instead only relies on the current test suite and uses invariant inference to generalize the behaviors of a program. Third, INVALIDATOR is fully automated. We have conducted our experiments on a dataset of 885 patches generated on real-world programs in Defects4J. Experiment results show that INVALIDATOR correctly classified 79% overfitting patches, accounting for 23% more overfitting patches being detected by the best baseline. INVALIDATOR also substantially outperforms the best baselines by 14% and 19% in terms of Accuracy and F-Measure, respectively.

Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.

The reward hypothesis posits that, "all of what we mean by goals and purposes can be well thought of as maximization of the expected value of the cumulative sum of a received scalar signal (reward)." We aim to fully settle this hypothesis. This will not conclude with a simple affirmation or refutation, but rather specify completely the implicit requirements on goals and purposes under which the hypothesis holds.

We present NusaCrowd, a collaborative initiative to collect and unite existing resources for Indonesian languages, including opening access to previously non-public resources. Through this initiative, we have has brought together 137 datasets and 117 standardized data loaders. The quality of the datasets has been assessed manually and automatically, and their effectiveness has been demonstrated in multiple experiments. NusaCrowd's data collection enables the creation of the first zero-shot benchmarks for natural language understanding and generation in Indonesian and its local languages. Furthermore, NusaCrowd brings the creation of the first multilingual automatic speech recognition benchmark in Indonesian and its local languages. Our work is intended to help advance natural language processing research in under-represented languages.

Importance: Social determinants of health (SDOH) are known to be associated with increased risk of suicidal behaviors, but few studies utilized SDOH from unstructured electronic health record (EHR) notes. Objective: To investigate associations between suicide and recent SDOH, identified using structured and unstructured data. Design: Nested case-control study. Setting: EHR data from the US Veterans Health Administration (VHA). Participants: 6,122,785 Veterans who received care in the US VHA between October 1, 2010, and September 30, 2015. Exposures: Occurrence of SDOH over a maximum span of two years compared with no occurrence of SDOH. Main Outcomes and Measures: Cases of suicide deaths were matched with 4 controls on birth year, cohort entry date, sex, and duration of follow-up. We developed an NLP system to extract SDOH from unstructured notes. Structured data, NLP on unstructured data, and combining them yielded seven, eight and nine SDOH respectively. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: In our cohort, 8,821 Veterans committed suicide during 23,725,382 person-years of follow-up (incidence rate 37.18 /100,000 person-years). Our cohort was mostly male (92.23%) and white (76.99%). Across the six common SDOH as covariates, NLP-extracted SDOH, on average, covered 84.38% of all SDOH occurrences. All SDOH, measured by structured data and NLP, were significantly associated with increased risk of suicide. The SDOH with the largest effects was legal problems (aOR=2.67, 95% CI=2.46-2.89), followed by violence (aOR=2.26, 95% CI=2.11-2.43). NLP-extracted and structured SDOH were also associated with suicide. Conclusions and Relevance: NLP-extracted SDOH were always significantly associated with increased risk of suicide among Veterans, suggesting the potential of NLP in public health studies.

The last several years have witnessed remarkable progress in video-and-language (VidL) understanding. However, most modern VidL approaches use complex and specialized model architectures and sophisticated pretraining protocols, making the reproducibility, analysis and comparisons of these frameworks difficult. Hence, instead of proposing yet another new VidL model, this paper conducts a thorough empirical study demystifying the most important factors in the VidL model design. Among the factors that we investigate are (i) the spatiotemporal architecture design, (ii) the multimodal fusion schemes, (iii) the pretraining objectives, (iv) the choice of pretraining data, (v) pretraining and finetuning protocols, and (vi) dataset and model scaling. Our empirical study reveals that the most important design factors include: temporal modeling, video-to-text multimodal fusion, masked modeling objectives, and joint training on images and videos. Using these empirical insights, we then develop a step-by-step recipe, dubbed VindLU, for effective VidL pretraining. Our final model trained using our recipe achieves comparable or better than state-of-the-art results on several VidL tasks without relying on external CLIP pretraining. In particular, on the text-to-video retrieval task, our approach obtains 61.2% on DiDeMo, and 55.0% on ActivityNet, outperforming current SOTA by 7.8% and 6.1% respectively. Furthermore, our model also obtains state-of-the-art video question-answering results on ActivityNet-QA, MSRVTT-QA, MSRVTT-MC and TVQA. Our code and pretrained models are publicly available at: https://github.com/klauscc/VindLU.

We explore unifying a neural segmenter with two-pass cascaded encoder ASR into a single model. A key challenge is allowing the segmenter (which runs in real-time, synchronously with the decoder) to finalize the 2nd pass (which runs 900 ms behind real-time) without introducing user-perceived latency or deletion errors during inference. We propose a design where the neural segmenter is integrated with the causal 1st pass decoder to emit a end-of-segment (EOS) signal in real-time. The EOS signal is then used to finalize the non-causal 2nd pass. We experiment with different ways to finalize the 2nd pass, and find that a novel dummy frame injection strategy allows for simultaneous high quality 2nd pass results and low finalization latency. On a real-world long-form captioning task (YouTube), we achieve 2.4% relative WER and 140 ms EOS latency gains over a baseline VAD-based segmenter with the same cascaded encoder.

OutlierDetection.jl is an open-source ecosystem for outlier detection in Julia. It provides a range of high-performance outlier detection algorithms implemented directly in Julia. In contrast to previous packages, our ecosystem enables the development highly-scalable outlier detection algorithms using a high-level programming language. Additionally, it provides a standardized, yet flexible, interface for future outlier detection algorithms and allows for model composition unseen in previous packages. Best practices such as unit testing, continuous integration, and code coverage reporting are enforced across the ecosystem. The most recent version of OutlierDetection.jl is available at https://github.com/OutlierDetectionJL/OutlierDetection.jl.